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Article

Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.

Molecular and cellular biology - 1 Aug 2004

Yu Ping, Di Prospero Nicholas A, Sapko Michael T, Cai Tao, Chen Amy, Melendez-Ferro Miguel, Du Fu, Whetsell William O, Guidetti Paolo, Schwarcz Robert, Tagle Danilo A

Abstract excerpt

Kynurenic acid (KYNA) can act as an endogenous modulator of excitatory neurotransmission and has been implicated in the pathogenesis of several neurological and psychiatric diseases. To evaluate its role in the brain, we disrupted the murine gene for kynurenine aminotransferase II (KAT II), the principal enzyme responsible for the synthesis of KYNA in the rat brain. mKat-2(-/-) mice showed no detectable KAT II...

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Identifiers

PMID: 15282294
DOI: 10.1128/MCB.24.16.6919-6930.2004
PMCID: PMC479723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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