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Article

Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.

Journal of neurochemistry - 1 Dec 2013

Mazarei Gelareh, Budac David P, Lu Ge, Adomat Hans, Tomlinson Guns Emma S, Möller Thomas, Leavitt Blair R

Abstract excerpt

Indoleamine 2,3 dioxygenase (Ido1), the first and rate-limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in the YAC128 mouse model of Huntington disease (HD). Our objective in this study was to delineate age-related KP alterations in this model. Three enzymes potentially catalyze the first step of the KP; Ido1 and Indoleamine 2,3 dioxygenase-2 were...

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Identifiers

PMID: 23786539
DOI: 10.1111/jnc.12350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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