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Article

Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring.

Biology of sex differences - 2 Apr 2025

Milosavljevic Snezana, Piroli Maria V, Sandago Emma J, Piroli Gerardo G, Smith Holland H, Beggiato Sarah, Frizzell Norma, Pocivavsek Ana

Abstract excerpt

BACKGROUND: Disruptions in brain development can impact behavioral traits and increase the risk of neurodevelopmental conditions such as autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder, often in sex-specific ways. Dysregulation of the kynurenine pathway (KP) of tryptophan metabolism has been implicated in cognitive and neurodevelopmental disorders....

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Identifiers

PMID: 40176166
DOI: 10.1186/s13293-025-00703-w
PMCID: PMC11967062

Genes

KMO

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