Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus.

doi:10.1523/JNEUROSCI.5631-03.2004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 May 2004

Alkondon Manickavasagon, Pereira Edna F R, Yu Ping, Arruda Emerson Z, Almeida Luis E F, Guidetti Paolo, Fawcett William P, Sapko Michael T, Randall William R, Schwarcz Robert, Tagle Danilo A, Albuquerque Edson X

Abstract excerpt

It has been postulated that endogenous kynurenic acid (KYNA) modulates alpha7* nicotinic acetylcholine receptor (nAChR) and NMDA receptor activities in the brain.a To test this hypothesis, alpha7* nAChR and NMDA receptor functions were studied in mice with a targeted null mutation in the gene encoding kynurenine aminotransferase II (mKat-2-/- mice), an enzyme responsible for brain KYNA synthesis. At 21 postnatal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to alpha7 Nicotinic Acetylcholine Receptor

Share to Choline

Share to Excitatory Amino Acid Antagonists

Share to Excitatory Postsynaptic Potentials

Share to Interneurons

Share to Sodium Channel Blockers

Share to Transaminases

Source

Open in PubMed Open full text

Identifiers

PMID: 15140935
DOI: 10.1523/JNEUROSCI.5631-03.2004
PMCID: PMC6729395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus.PMID 15140935Read ↗

Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.Semantic proximity Read ↗

Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice.Semantic proximity Read ↗

Research tool: Validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches.Semantic proximity Read ↗

Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors.Semantic proximity Read ↗

Kynurenic acid promotes activity-dependent synaptic pruning in schizophreniaSemantic proximity Read ↗

Reduced Chrna7 expression in mice is associated with decreases in hippocampal markers of inhibitory function: implications for neuropsychiatric diseases.Semantic proximity Read ↗

Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications.Semantic proximity Read ↗

Identification of four classes of brain nicotinic receptors using beta2 mutant mice.Semantic proximity Read ↗

Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine.Semantic proximity Read ↗

Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure.Semantic proximity Read ↗

Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspringSemantic proximity Read ↗

Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.