Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs.

PloS one - 1 Jan 2013

Baptista Marco A S, Dave Kuldip D, Frasier Mark A, Sherer Todd B, Greeley Melanie, Beck Melissa J, Varsho Julie S, Parker George A, Moore Cindy, Churchill Madeline J, Meshul Charles K, Fiske Brian K

Abstract excerpt

The objective of this study was to evaluate the pathology time course of the LRRK2 knockout rat model of Parkinson's disease at 1-, 2-, 4-, 8-, 12-, and 16-months of age. The evaluation consisted of histopathology and ultrastructure examination of selected organs, including the kidneys, lungs, spleen, heart, and liver, as well as hematology, serum, and urine analysis. The LRRK2 knockout rat, starting at 2-months...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Kidney
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Serine-Threonine Kinases

Share to Rats, Mutant Strains

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 24244710
DOI: 10.1371/journal.pone.0080705
PMCID: PMC3828242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs.PMID 24244710Read ↗

Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological HomeostasisSemantic proximity Read ↗

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway.Semantic proximity Read ↗

Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.Semantic proximity Read ↗

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.Semantic proximity Read ↗

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2.Semantic proximity Read ↗

LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis.Semantic proximity Read ↗

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.Semantic proximity Read ↗

LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation.Semantic proximity Read ↗

Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.Semantic proximity Read ↗

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.Semantic proximity Read ↗

Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.