Article
trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein.
Journal of virology - 1 Oct 1992
Albrecht H, Shakhov A N, Jongeneel C V
Abstract excerpt
In a cotransfection assay, the human T-cell leukemia virus type I Tax1 gene product specifically activated transcription from the mouse tumor necrosis factor alpha promoter. The activation patterns of 5' deletion mutants, artificial enhancer constructs, and point mutations in the promoter indicate that the major Tax1-responsive element is a site at position -655 which binds the NF-kappa B/rel and NF-GMa...
Topics
- Animals
- Base Sequence
- Chloramphenicol O-Acetyltransferase
- Enhancer Elements, Genetic
- Gene Products, tax
- Mice
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Plasmids
- Promoter Regions, Genetic