Transactivation of the human T-cell lymphotropic virus type 1 Tax1-responsive 21-base-pair repeats requires Holo-TFIID and TFIIA.

doi:10.1128/JVI.69.8.5077-5086.1995

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Article

Transactivation of the human T-cell lymphotropic virus type 1 Tax1-responsive 21-base-pair repeats requires Holo-TFIID and TFIIA.

Journal of virology - 1 Aug 1995

Duvall J F, Kashanchi F, Cvekl A, Radonovich M F, Piras G, Brady J N

Abstract excerpt

The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent for adult T-cell leukemia and tropical spastic paraparesis/HTLV-1-associated myelopathy. The HTLV-1 Tax1 gene product has been shown to transactivate transcription of viral and cellular promoters. To examine the biochemical mechanism of Tax1 transactivation, we have developed an in vitro transactivation assay in which wild-type Tax1 is...

Topics

Animals
Base Composition
Base Sequence
Cell Line
Gene Products, tax
HeLa Cells
Human T-lymphotropic virus 1
Humans
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Spodoptera

Templates, Genetic

Transcription Factor TFIIA

Transcription Factor TFIID

Transcription Factors

Transcription, Genetic

Source

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Identifiers

PMID: 7609077
DOI: 10.1128/JVI.69.8.5077-5086.1995
PMCID: PMC189325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7609077-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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