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Article

Mutational analysis of the HTLV-I trans-activator, Tax.

FEBS letters - 4 Nov 1991

Heder A, Paca-Uccaralertkun S, Boros I

Abstract excerpt

The gene coding for the trans-activating factor (Tax) of the human T-cell leukemia virus, type I (HTLV-I) was mutagenized in vitro using oligonucleotide-directed mutagenesis and recombinant DNA techniques. All except one of the mutagenized tax constructs failed to trans-activate the HTLV-I LTR in a eukaryotic test system. Moreover, negative Tax mutant Arg-39----Gly was found to be trans-dominant. This observation...

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PMID: 1959609
DOI: 10.1016/0014-5793(91)80869-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutational analysis of the HTLV-I trans-activator, Tax.PMID 1959609Read ↗

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Activation of a cryptic splice site in the tax gene of HTLV-I by a single nucleotide change.Semantic proximity Read ↗

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Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.Semantic proximity Read ↗

trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein.Semantic proximity Read ↗

Expression of the HTLV-I tax transactivator in yeast: correlation between phenotypic alterations and tax function in higher eukaryotes.Semantic proximity Read ↗

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.Semantic proximity Read ↗

Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.Semantic proximity Read ↗

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Mutational analysis of human T-cell leukemia virus type 2 Tax.Semantic proximity Read ↗

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