Article
Estradiol represses human T-cell leukemia virus type 1 Tax activation of tumor necrosis factor-alpha gene transcription.
The Journal of biological chemistry - 22 Nov 2002
Tzagarakis-Foster Christina, Geleziunas Romas, Lomri Abderrahim, An Jinping, Leitman Dale C
Abstract excerpt
Adult T-cell leukemia is caused by human T-cell leukemia virus type I (HTLV-I). The HTLV-I Tax protein is essential for clinical manifestations because it activates viral and cellular gene transcription. Tax enhances production of tumor necrosis factor-alpha (TNF-alpha), which may lead to bone and joint destruction. Because estrogens might prevent osteoporosis by repressing TNF-alpha gene transcription, we...
Topics
- Binding Sites
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Estradiol
- Female
- Gene Expression Regulation
- Gene Products, tax
- Human T-lymphotropic virus 1
- Humans
- Male
- Mutation
- NF-kappa B
- NFATC Transcription Factors