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Article

Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y.

Molecular and cellular biology - 1 Mar 1997

Pise-Masison C A, Dittmer J, Clemens K E, Brady J N

Abstract excerpt

Tax1, a potent activator of human T-cell lymphotropic virus type 1 (HTLV-1) transcription, has been shown to modulate expression of many cellular genes. Tax1 does not bind DNA directly but regulates transcription through protein-protein interactions with sequence-specific transcription factors. Using the yeast two-hybrid system to screen for proteins which interact with Tax1, we isolated the B subunit of the...

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Identifiers

PMID: 9032250
DOI: 10.1128/MCB.17.3.1236
PMCID: PMC231848

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