Article
Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.
Genes & development - 1 Nov 1990
Smith M R, Greene W C
Abstract excerpt
The type I human T-cell leukemia virus (HTLV-I) encodes a 40-kD nuclear trans-regulatory protein termed Tax that transcriptionally activates the HTLV-I long terminal repeat (LTR), as well as select [corrected] cellular and heterologous viral promoters. Tax does not bind DNA specifically but, rath...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Enhancer Elements, Genetic
- Exons
- Fluorescent Antibody Technique
- Gene Products, tax
- Genes, pX
- Human T-lymphotropic virus 1
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Repetitive Sequences, Nucleic Acid
- Transcription, Genetic
- Transcriptional Activation
- Transfection
- Zinc Fingers