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Article

The Wilms' tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains.

Nucleic acids research - 15 Jul 1999

Lee T H, Moffett P, Pelletier J

Abstract excerpt

We have studied the ability of the wt1 tumor suppressor gene product to repress different classes of activation domains previously shown to stimulate the initiation and elongation steps of RNA polymerase II transcription in vivo. Repression assays revealed that WT1 represses all three classes of activation domains: Sp1 and CTF, which stimulate initiation (type I), human immunodeficiency virus type I Tat fused to...

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Identifiers

PMID: 10390530
DOI: 10.1093/nar/27.14.2889
PMCID: PMC148503

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