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Article

Molecular mechanisms of cellular transformation by HTLV-1 Tax.

Oncogene - 5 Sept 2005

Grassmann Ralph, Aboud Mordechai, Jeang Kuan-Teh

Abstract excerpt

The HTLV Tax protein is crucial for viral replication and for initiating malignant transformation leading to the development of adult T-cell leukemia. Tax has been shown to be oncogenic, since it transforms and immortalizes rodent fibroblasts and human T-lymphocytes. Through CREB, NF-kappaB and SRF pathways Tax transactivates cellular promoters including those of cytokines (IL-13, IL-15), cytokine receptors...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Human T-lymphotropic virus 1

Share to Receptors, Cell Surface

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Source

Identifiers

PMID: 16155604
DOI: 10.1038/sj.onc.1208978

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular mechanisms of cellular transformation by HTLV-1 Tax.PMID 16155604Read ↗

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