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SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription

11 Jun 2015

Abstract excerpt

UNLABELLED: Human T-cell leukemia virus type 1 (HTLV-1)-associated diseases are poorly treatable, and HTLV-1 vaccines are not available. High proviral load is one major risk factor for disease development. HTLV-1 encodes Tax oncoprotein, which activates transcription from viral long terminal repeats (LTR) and various types of cellular promoters. Counteracting Tax function might have prophylactic and therapeutic...

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PMID: 26063426
DOI: 10.1128/jvi.01229-15

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