Article
Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.
The Journal of experimental medicine - 1 Jul 1990
Kim S J, Kehrl J H, Burton J, Tendler C L, Jeang K T, Danielpour D, Thevenin C, Kim K Y, Sporn M B, Roberts A B
Abstract excerpt
We examined the effect of the human T lymphotropic virus type 1 (HTLV-I) Tax gene product on the human transforming growth factor beta 1 (TGF-beta 1) promoter. Transfection of deleted constructs of the TGF-beta 1 promoter revealed regions homologous with AP-1 binding sites that were required for...
Topics
- Cell Line
- Chromosome Deletion
- Gene Expression
- Human T-lymphotropic virus 1
- Humans
- Leukemia, T-Cell
- Mutation
- Plasmids
- Promoter Regions, Genetic
- RNA, Messenger
- Restriction Mapping
- Trans-Activators
- Transfection