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Article

Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease.

Current Alzheimer research - 1 Jan 2022

Šerý Omar, Zeman Tomáš, Hálová Alice, Janout Vladimír, Janoutová Jana, Lochman Jan, Balcar Vladimir J

Abstract excerpt

BACKGROUND: Insulin-degrading enzyme (IDE) is a widely distributed Zn2+-binding metalloprotease that cleaves multiple short and medium-sized peptides prone to form β-structures. These include insulin and amyloid-β peptides. Accumulation and fibrillation of amyloid-β peptides leading to the formation of amyloid plaques is a characteristic sign of Alzheimer's disease (AD) pathology. OBJECTIVE: The study...

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PMID: 35236268
DOI: 10.2174/1567205019666220302120950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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