Article
Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury.
The American journal of pathology - 1 Aug 2004
Schaefer Liliana, Mihalik Daniel, Babelova Andrea, Krzyzankova Miroslava, Gröne Hermann-Josef, Iozzo Renato V, Young Marian F, Seidler Daniela G, Lin Guoqing, Reinhardt Dieter P, Schaefer Roland M
Abstract excerpt
There is growing evidence that the two small leucine-rich proteoglycans biglycan and decorin regulate the assembly of connective tissues and alter cell behavior during development and pathological processes. In this study, we have used an experimental animal model of unilateral ureteral ligation and mice deficient in either biglycan or decorin. We discovered that pressure-induced injury to the wild-type kidneys...
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