Article
Models for studies of proteoglycans in kidney pathophysiology.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Harvey Scott J
Abstract excerpt
Proteoglycans (PGs) impact many aspects of kidney health and disease. Models that permit genetic dissection of PG core protein and glycosaminoglycan (GAG) function have been instrumental to understanding their roles in the kidney. Matrix-associated PGs do not serve critical structural roles in the organ, nor do they contribute significantly to the glomerular barrier under normal conditions, but their abnormal...
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