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Article

Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition.

PloS one - 1 Jan 2012

Wu Zhiping, Aron Abraham W, Macksoud Elyse E, Iozzo Renato V, Hai Chi-Ming, Lechner Beatrice E

Abstract excerpt

Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of reproductive tissues and muscle. Mice deficient in biglycan display a mild muscular dystrophy, and, along with mice deficient in decorin, are models of Ehlers-Danlos...

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Source

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Identifiers

PMID: 22253749
DOI: 10.1371/journal.pone.0029627
PMCID: PMC3258236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition.PMID 22253749Read ↗

A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorinSemantic proximity Read ↗

Biglycan and decorin differentially regulate signaling in the fetal membranesSemantic proximity Read ↗

Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases.Semantic proximity Read ↗

Biglycan knockout mice: new models for musculoskeletal diseases.Semantic proximity Read ↗

Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues.Semantic proximity Read ↗

Biglycan Deficiency Causes Spontaneous Aortic Dissection and Rupture in MiceSemantic proximity Read ↗

Developmental regulation of biglycan expression in muscle and tendonSemantic proximity Read ↗

Decorin: a multifunctional proteoglycan involved in oocyte maturation and trophoblast migrationSemantic proximity Read ↗

Investigating the temporal roles of decorin and biglycan in tendon healingSemantic proximity Read ↗

Dystroglycan Is Essential for Early Embryonic Development: Disruption of Reichert's Membrane in Dag1-Null MiceSemantic proximity Read ↗

Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury.Semantic proximity Read ↗

Decorin counteracts disease progression in mice with recessive dystrophic epidermolysis bullosaSemantic proximity Read ↗

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