Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ureteral obstruction promotes proliferation and differentiation of the renal urothelium into a bladder-like phenotype.

Kidney international - 1 Aug 2012

Girshovich Alexey, Vinsonneau Christophe, Perez Joelle, Vandermeersch Sophie, Verpont Marie-Christine, Placier Sandrine, Jouanneau Chantal, Letavernier Emmanuel, Baud Laurent, Haymann Jean-Philippe

Abstract excerpt

The renal urothelium, the monolayered epithelium that covers the papilla, is the direct target of increased pressure during obstruction, yet most studies have mainly focused on tubules, fibroblasts, and inflammatory cells. We studied this epithelium in a unilateral ureteral obstruction mouse mode land found that it was disrupted and had broken tight junctions, enlarged intercellular space, with loss of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transdifferentiation
Share to Mechanotransduction, Cellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pressure

Share to Receptor, Fibroblast Growth Factor, Type 2

Share to Ureteral Obstruction

Share to Urinary Bladder

Share to Urothelium

Share to Vitamin A

Source

Identifiers

PMID: 22513823
DOI: 10.1038/ki.2012.110

Genes

FGF7
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ureteral obstruction promotes proliferation and differentiation of the renal urothelium into a bladder-like phenotype.PMID 22513823Read ↗

Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis.Semantic proximity Read ↗

Urothelial proliferation and regeneration after spinal cord injury.Semantic proximity Read ↗

Advances in understanding vertebrate nephrogenesisSemantic proximity Read ↗

Uroplakins: new molecular players in the biology of urinary tract malformations.Semantic proximity Read ↗

The ureteric bud epithelium: Morphogenesis and roles in metanephric kidney patterningSemantic proximity Read ↗

Genetic and developmental basis for urinary tract obstruction.Semantic proximity Read ↗

Epithelial nephrogenesisSemantic proximity Read ↗

<i>In vitro</i> plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signalsSemantic proximity Read ↗

Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases.Semantic proximity Read ↗

Kidney morphogenesis: cellular and molecular regulation.Semantic proximity Read ↗

Epithelial-to-Mesenchymal Transition Is a Potential Pathway Leading to Podocyte Dysfunction and ProteinuriaSemantic proximity Read ↗

Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.