Article
Lack of association between 5HT2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Aug 2004
Etain Bruno, Rousseva Angela, Roy Isabelle, Henry Chantal, Malafosse Alain, Buresi Catherine, Preisig Martin, Rayah Fadila, Leboyer Marion, Bellivier Frank
Abstract excerpt
Bipolar affective disorder (BPAD) is a complex psychiatric disorder with a major genetic contribution. Abnormalities in serotonergic function have been implicated in its aetiology. The 5HT2A receptor (5HT2AR) gene is a strong candidate gene for involvement in BPAD, but previous association studies have reported conflicting results. These data are difficult to interpret because most negative results were obtained...
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