Article
5-HT2A receptor and bipolar affective disorder: association studies in affected patients.
Neuroscience letters - 14 Mar 1997
Arranz M J, Erdmann J, Kirov G, Rietschel M, Sodhi M, Albus M, Ball D, Maier W, Davies N, Franzek E, Abusaad I, Weigelt B, Murray R, Shimron-Abarbanell D, Kerwin R, Propping P, Sham P, Nöthen M M, Collier D A
Abstract excerpt
The aim of this study was to investigate the possible involvement of genetic variation in serotonin receptors in the aetiology of bipolar affective disorder. The 5-HT2A receptor gene was systematically screened for genetic variants by single strand conformation polymorphism (SSCP) methods in subjects with bipolar affective disorder. Four polymorphisms (two structural changes, Thr25Asn and His4 M52Tyr, and two...
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