Article
Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study.
European journal of human genetics : EJHG - 1 May 2004
Mendlewicz Julien, Massat Isabelle, Souery Daniel, Del-Favero Jurgen, Oruc Lilijana, Nöthen Markus M, Blackwood Douglas, Muir Walter, Battersby Sharon, Lerer Beny, Segman Ronen H, Kaneva Radka, Serretti Alessandro, Lilli Roberta, Lorenzi Christian, Jakovljevic Miro, Ivezic Sladana, Rietschel Marcella, Milanova Vihra, Van Broeckhoven Christine
Abstract excerpt
The available data from preclinical and pharmacological studies on the role of the serotonin transporter (5-HTT) support the hypothesis that a dysfunction in brain serotonergic system activity contributes to the vulnerability to affective disorders (AD). 5-HTT is the major site of serotonin reuptake into the presynaptic neuron, and it has been shown that the polymorphic repeat polymorphism in the 5-HTT promotor...
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