Article
No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism.
Psychiatry research - 5 May 1997
Mahieu B, Souery D, Lipp O, Mendelbaum K, Verheyen G, De Maertelaer V, Van Broeckhoven C, Mendlewicz J
Abstract excerpt
The serotonergic system is implicated in the pathogenesis of affective disorders. In particular, the role of the postsynaptic 5-hydroxytryptamine (serotonin) type 2 receptor (5-HT2) has been documented by several studies. The 5-HT2A receptor gene located on chromosome 13 (13q14-21) can be considered a candidate gene for bipolar affective disorder (BPAD). We tested association between a 5-HT2A receptor DNA variant...
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