Article
A YY1-binding site is required for accurate human LINE-1 transcription initiation.
Nucleic acids research - 1 Jan 2004
Athanikar Jyoti N, Badge Richard M, Moran John V
Abstract excerpt
The initial step in Long Interspersed Element-1 (LINE-1) retrotransposition requires transcription from an internal promoter located within its 5'-untranslated region (5'-UTR). Previous studies have identified a YY1 (Yin Yang 1)-binding site as an important sequence in LINE-1 transcription. Here, we demonstrate that mutations in the YY1-binding site have only minor effects on transcription activation of the...
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