Article
YY1 is a positive regulator of transcription of the Col1a1 gene.
The Journal of biological chemistry - 19 Oct 2001
Riquet F B, Tan L, Choy B K, Osaki M, Karsenty G, Osborne T F, Auron P E, Goldring M B
Abstract excerpt
Both cell-specific and ubiquitous transcription factors in fibroblasts have been identified as critical for expression of the Col1a1 gene, which encodes the alpha1 chain of type I collagen. Here, we report that Yin Yang 1 (YY1) binds to the Col1a1 promoter immediately upstream of the TATA box, and we examine the functional implications of YY1 binding for regulation of Col1a1 gene expression in BALBc/3T3...
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