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Article

An Upstream YY1 Binding Site on the HIV-1 LTR Contributes to Latent Infection

8 Oct 2013

Abstract excerpt

During HIV-1 infection a population of latently infected cells is established. This population is the major obstacle preventing total eradication of the virus from AIDS patients. HIV-1 latency is thought to arise by various mechanisms including repressive chromatin modifications. Transcription factors such as YY1 have been shown to facilitate repressive chromatin modifications by the recruitment of histone...

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PMID: 24116200
DOI: 10.1371/journal.pone.0077052

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