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Article

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

The Journal of biological chemistry - 5 Jan 1992

Conklin B R, Chabre O, Wong Y H, Federman A D, Bourne H R

Abstract excerpt

Gq mediates hormonal stimulation of phosphoinositide-specific phospholipase C (PI-PLC). We mutated the alpha subunit of Gq (alpha q) to replace arginine 183 with cysteine. Mutations that substitute cysteine for the corresponding arginine residues of alpha s and alpha i2 constitutively activate their respective effector pathways, creating the gsp and gip2 oncogenes. Transient expression of alpha q-R183C in COS-7...

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PMID: 1309740

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