Article
Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2004
Ferrari Guido, Neal Wesley, Ottinger Janet, Jones Anizsa M, Edwards Bradley H, Goepfert Paul, Betts Michael R, Koup Richard A, Buchbinder Susan, McElrath M Juliana, Tartaglia Jim, Weinhold Kent J
Abstract excerpt
According to a number of previous reports, control of HIV replication in humans appears to be linked to the presence of anti-HIV-1 Gag-specific CD8 responses. During the chronic phase of HIV-1 infection, up to 75% of the HIV-infected individuals who express the histocompatibility leukocyte Ag (HLA)-A*0201 recognize the Gag p17 SLYNTVATL (aa residues 77-85) epitope (SL9). However, the role of the anti-SL9 CD8 CTL...
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