Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens

23 Jan 2019

Abstract excerpt

It is likely necessary for an effective AIDS vaccine to elicit CD8 + T cells with the ability to recognize circulating HIV-1 and suppress its replication. We recently developed novel bivalent mosaic T-cell vaccine immunogens composed of conserved regions of the Gag and Pol proteins matched to at least 80% globally circulating HIV-1 isolates. Nevertheless, it remains to be proven if vaccination with these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Herpesvirus Infections and Treatments
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30674626
DOI: 10.1128/jvi.02142-18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine ImmunogensPMID 30674626Read ↗

CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication.Semantic proximity Read ↗

HIV-1 vaccine immunogen design strategiesSemantic proximity Read ↗

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.Semantic proximity Read ↗

Challenges in the design of a T cell vaccine in the context of HIV-1 diversity.Semantic proximity Read ↗

Translational research insights from completed HIV vaccine efficacy trials.Semantic proximity Read ↗

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.Semantic proximity Read ↗

HIV-1 vaccine design: harnessing diverse lymphocytes to conquer a diverse pathogen.Semantic proximity Read ↗

Shared HIV envelope-specific B cell clonotypes induced by a pox-protein vaccine regimenSemantic proximity Read ↗

Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention.Semantic proximity Read ↗

Will we be able to 'spot' an effective HIV-1 vaccine?Semantic proximity Read ↗

The changing face of HIV vaccine research.Semantic proximity Read ↗

The Emerging Role for CTL Epitope Specificity in HIV Cure EffortsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.