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Article

Cytomegalovirus Vectors Violate CD8 <sup>+</sup> T Cell Epitope Recognition Paradigms

23 May 2013

Abstract excerpt

CD8(+) T cell responses focus on a small fraction of pathogen- or vaccine-encoded peptides, and for some pathogens, these restricted recognition hierarchies limit the effectiveness of antipathogen immunity. We found that simian immunodeficiency virus (SIV) protein-expressing rhesus cytomegalovirus (RhCMV) vectors elicit SIV-specific CD8(+) T cells that recognize unusual, diverse, and highly promiscuous epitopes,...

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PMID: 23704576
DOI: 10.1126/science.1237874

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