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Article

Transcription-dependent somatic hypermutation occurs at similar levels on functional and nonfunctional rearranged IgH alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2004

Delpy Laurent, Sirac Christophe, Le Morvan Caroline, Cogné Michel

Abstract excerpt

Allelic exclusion of IgH chain expression is stringently established before or during early B cell maturation. It likely relies both on cellular mechanisms, selecting those cells in which a single receptor allows the best possible Ag response, and on molecular restrictions of gene accessibility to rearrangement. The extent to which transcriptional control may be involved is unclear. Transcripts arising from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15265916
DOI: 10.4049/jimmunol.173.3.1842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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