Article
ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer.
Cancer research - 15 Aug 2001
Rökman A, Ikonen T, Mononen N, Autio V, Matikainen M P, Koivisto P A, Tammela T L, Kallioniemi O P, Schleutker J
Abstract excerpt
The ELAC2/HPC2 gene at 17p11 is the first candidate gene identified for human prostate cancer (PRCA) based on linkage analysis and positional cloning (S. V. Tavtigian et al. Nat. Genet., 27:172-180, 2001). A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general...
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