Article
Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer.
American journal of human genetics - 1 Apr 2001
Xu J, Zheng S L, Carpten J D, Nupponen N N, Robbins C M, Mestre J, Moses T Y, Faith D A, Kelly B D, Isaacs S D, Wiley K E, Ewing C M, Bujnovszky P, Chang B, Bailey-Wilson J, Bleecker E R, Walsh P C, Trent J M, Meyers D A, Isaacs W B
Abstract excerpt
To investigate the relationship between HPC2/ELAC2 and prostate cancer risk, we performed the following analyses: (1) a linkage study of six markers in and around the HPC2/ELAC2 gene at 17p11 in 159 pedigrees with hereditary prostate cancer (HPC); (2) a mutation-screening analysis of all coding exons of the gene in 93 probands with HPC; (3) family-based and population-based association study of common HPC2/ELAC2...
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