Article
Mutational analysis of SPANX genes in families with X-linked prostate cancer.
The Prostate - 1 Jun 2007
Kouprina Natalay, Noskov Vladimir N, Solomon Greg, Otstot John, Isaacs William, Xu Jianfeng, Schleutker Johanna, Larionov Vladimir
Abstract excerpt
BACKGROUND: Previous genetic linkage studies identified a locus for susceptibility to prostate cancer called HPCX at Xq27. The candidate region contains two clusters of SPANX genes. The first cluster called SPANX-A/D includes SPANX-A1, SPANX-A2, SPANX-B, SPANX-C, and SPANX-D; the second cluster called SPANX-N includes SPANX-N1, SPANX-N2, SPANX-N3, and SPANX-N4. The SPANX genes encode cancer-testis (CT) specific...
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