Article
A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region.
Human genetics - 1 Aug 2005
Baffoe-Bonnie Agnes B, Smith Jeffrey R, Stephan Dietrich A, Schleutker Johanna, Carpten John D, Kainu Tommi, Gillanders Elizabeth M, Matikainen Mika, Teslovich Tanya M, Tammela Teuvo, Sood Raman, Balshem Andrew M, Scarborough Sheehan D, Xu Jianfeng, Isaacs William B, Trent Jeffrey M, Kallioniemi Olli-P, Bailey-Wilson Joan E
Abstract excerpt
BACKGROUND: Prostate cancer (PRCA) is the most common cancer in males in the western world. In Finland PRCA has an age-adjusted incidence of 81.5 per 100,000. We previously reported that in Finland, the late-onset cases in families with "no-male-to-male" (NMM) transmission of PRCA accounted for most of the linkage to the HPCX region (Xq27-28). The aim of the present study was to test for linkage disequilibrium...
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