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Article

Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families.

Genes, chromosomes & cancer - 1 Oct 2012

Kouprina Natalay, Lee Nicholas C O, Pavlicek Adam, Samoshkin Alexander, Kim Jung-Hyun, Lee Hee-Sheung, Varma Sudhir, Reinhold William C, Otstot John, Solomon Greg, Davis Sean, Meltzer Paul S, Schleutker Johanna, Larionov Vladimir

Abstract excerpt

Several linkage studies provided evidence for the presence of the hereditary prostate cancer locus, HPCX1, at Xq27-q28. The strongest linkage peak of prostate cancer overlies a variable region of ~750 kb at Xq27 enriched by segmental duplications (SDs), suggesting that the predisposition to prost...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22733720
DOI: 10.1002/gcc.21977
PMCID: PMC3412920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22733720-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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