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Article

The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity.

The Journal of biological chemistry - 10 Sept 2004

Boldt Henning B, Kjaer-Sorensen Kasper, Overgaard Michael T, Weyer Kathrin, Poulsen Christine B, Sottrup-Jensen Lars, Conover Cheryl A, Giudice Linda C, Oxvig Claus

Abstract excerpt

The Lin12-Notch repeat (LNR) module of about 35 residues is a hallmark of the Notch receptor family. Three copies, arranged in tandem, are invariably present in the extracellular portion of the Notch receptors. Although their function is unknown, genetic and biochemical data indicate that the LNR modules participate in the regulation of ligand-induced proteolytic cleavage of the Notch receptor, a prerequisite to...

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PMID: 15262980
DOI: 10.1074/jbc.M405222200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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