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Article

PAPP-A: a promising therapeutic target for healthy longevity

29 Dec 2016

Abstract excerpt

Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the...

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PMID: 28035757
DOI: 10.1111/acel.12564

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