Article
Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.
The Biochemical journal - 1 Oct 2002
Laursen Lisbeth S, Overgaard Michael T, Nielsen Claus G, Boldt Henning B, Hopmann Kathrin H, Conover Cheryl A, Sottrup-Jensen Lars, Giudice Linda C, Oxvig Claus
Abstract excerpt
Human pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system. PAPP-A belongs to the metzincin superfamily of zinc metalloproteinases, and is the...
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