Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity.

The Journal of biological chemistry - 5 Apr 2013

Kjaer-Sorensen Kasper, Engholm Ditte H, Kamei Hiroyasu, Morch Maria G, Kristensen Anisette O, Zhou Jianfeng, Conover Cheryl A, Duan Cunming, Oxvig Claus

Abstract excerpt

Pregnancy-associated plasma protein-A (PAPP-A) is a large metalloproteinase specifically cleaving insulin-like growth factor (IGF) binding proteins, causing increased IGF bioavailability and, hence, local regulation of IGF receptor activation. We have identified two highly conserved zebrafish homologs of the human PAPP-A gene. Expression of zebrafish Papp-a, one of the two paralogs, begins during gastrulation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Developmental
Share to Genome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to In Situ Hybridization

Share to Metalloproteases

Share to Recombinant Proteins

Share to Somatomedins

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 23430244
DOI: 10.1074/jbc.M112.426304
PMCID: PMC3617297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity.PMID 23430244Read ↗

Papp-a2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos.Semantic proximity Read ↗

The Pregnancy-Associated Plasma Protein-A (PAPP-A) StorySemantic proximity Read ↗

Pregnancy-Associated Plasma Protein-A2 (PAPP-A2): Tissue Expression and Biological Consequences of Gene Knockout in MiceSemantic proximity Read ↗

Expression of recombinant murine pregnancy‐associated plasma protein‐A (PAPP‐A) and a novel variant (PAPP‐Ai) with differential proteolytic activitySemantic proximity Read ↗

PAPP-A: a promising therapeutic target for healthy longevitySemantic proximity Read ↗

The role of PAPP-A in the IGF system: location, location, locationSemantic proximity Read ↗

Pregnancy-associated plasma protein-A (PAPP-A): A local regulator of IGF bioavailability through cleavage of IGFBPsSemantic proximity Read ↗

The metalloproteinase Papp-aa functions as a molecular switch linking IGF signaling to adaptive epithelial growthSemantic proximity Read ↗

The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity.Semantic proximity Read ↗

Biology of pregnancy‐associated plasma protein‐A in relation to prenatal diagnostics: an overviewSemantic proximity Read ↗

Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cellsSemantic proximity Read ↗

Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.