Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Papp-a2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos.

Journal of cell science - 1 Dec 2014

Kjaer-Sorensen Kasper, Engholm Ditte H, Jepsen Malene R, Morch Maria G, Weyer Kathrin, Hefting Louise L, Skov Louise L, Laursen Lisbeth S, Oxvig Claus

Abstract excerpt

Pregnancy-associated plasma protein A2 (PAPP-A2, also known as pappalysin-2) is a large metalloproteinase that is known to be required for normal postnatal growth and bone development in mice. We here report the detection of zebrafish papp-a2 mRNA in the chordamesoderm, notochord and lower jaw of zebrafish (Danio rerio) embryos, and that papp-a2-knockdown embryos display broadened axial mesoderm, notochord bends...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Cartilage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Insulin-Like Growth Factor Binding Protein 3

Share to Neovascularization, Physiologic

Share to Receptors, Notch

Share to Zebrafish Proteins

Source

Identifiers

PMID: 25236600
DOI: 10.1242/jcs.152587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Papp-a2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos.PMID 25236600Read ↗

Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity.Semantic proximity Read ↗

Pregnancy-Associated Plasma Protein-A2 (PAPP-A2): Tissue Expression and Biological Consequences of Gene Knockout in MiceSemantic proximity Read ↗

Low IGF-I Bioavailability Impairs Growth and Glucose Metabolism in a Mouse Model of Human PAPPA2 p.Ala1033Val MutationSemantic proximity Read ↗

Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouseSemantic proximity Read ↗

The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity.Semantic proximity Read ↗

PAPP-A2 expression by osteoblasts is required for normal postnatal growth in mice.Semantic proximity Read ↗

The Pregnancy-Associated Plasma Protein-A (PAPP-A) StorySemantic proximity Read ↗

The metalloproteinase Papp-aa functions as a molecular switch linking IGF signaling to adaptive epithelial growthSemantic proximity Read ↗

Pregnancy associated plasma protein A2 (PAPP-A2) affects bone size and shape and contributes to natural variation in postnatal growth in mice.Semantic proximity Read ↗

The role of PAPP-A in the IGF system: location, location, locationSemantic proximity Read ↗

Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cellsSemantic proximity Read ↗

Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.