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Biology of pregnancy‐associated plasma protein‐A in relation to prenatal diagnostics: an overview

30 Aug 2010

Abstract excerpt

Pregnancy-associated plasma protein-A (PAPP-A) is highly efficient as a serum marker in first-trimester screening for chromosomal abnormalities. Furthermore, there is increasing evidence that low levels of PAPP-A in the first trimester are associated with adverse pregnancy outcomes such as preterm delivery, intrauterine growth retardation, preeclampsia, and stillbirth. PAPP-A is a glycoprotein, produced in the...

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PMID: 20804336
DOI: 10.3109/00016349.2010.505639

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