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Article

One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology.

EMBO molecular medicine - 1 Oct 2017

Argente Jesús, Chowen Julie A, Pérez-Jurado Luis A, Frystyk Jan, Oxvig Claus

Abstract excerpt

The discovery of a mutation in a specific gene can be very important for determining the pathophysiology underlying the disease of a patient and may also help to decide the best treatment protocol on an individual basis. However, sometimes the discovery of mutations in new proteins advances our comprehension in a more widespread manner. The growth hormone (GH)/insulin-like growth factor (IGF)-1 axis is...

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Topics

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Share to Glycoproteins
Share to Human Growth Hormone
Share to Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Mice, Transgenic

Share to Mutation

Share to Proteolysis

Source

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Identifiers

PMID: 28801361
DOI: 10.15252/emmm.201707950
PMCID: PMC5623872

Genes

STC1
STC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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