Article

The metalloproteinase Papp-aa functions as a molecular switch linking IGF signaling to adaptive epithelial growth

2019-10-03

Abstract excerpt

Human patients carrying inactivating mutations in the pregnancy-associated plasma protein-a2 (PAPP-A2) gene display short status and lower bone mineral density. The underlying mechanisms are not well understood. Using a zebrafish model, here we report a [Ca 2+ ]-dependent mechanism by which Papp-aa regulates bone calcification via promoting Ca 2+ -transporting epithelial cell (ionocyte) reactivation. Ionocyte, n...

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Literature Corpus work: e3842cf5-9e7b-5a23-8a73-c8cdbbf1a1d6
DOI: 10.1101/792978

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