The role of PAPP-A in the IGF system: location, location, location

Abstract excerpt

Although discovered as a placental protein present abundantly in the circulation of pregnant women, pregnancy-associated plasma protein-A (PAPP-A) is widely expressed in multiple tissues. PAPP-A is a highly specific metalloproteinase binding tightly to glycosaminoglycans present on the surface of cells. By cleaving a subset of insulin-like growth factor binding proteins (IGFBPs), PAPP-A thus functions within...

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• Genetic Syndromes and Imprinting
• Growth Hormone and Insulin-like Growth Factors
• Metabolism, Diabetes, and Cancer