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Article

Cell surface adhesion of pregnancy‐associated plasma protein‐A is mediated by four clusters of basic residues located in its third and fourth CCP module

22 Mar 2004

Abstract excerpt

The metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) cleaves a subset of insulin-like growth factor binding proteins (IGFBP), which inhibit the activities of insulin-like growth factor (IGF). Through this proteolytic activity, PAPP-A is believed to regulate IGF bioavailability in several biological systems, including the human reproductive system and the cardiovascular system. PAPP-A adheres to...

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PMID: 15066178
DOI: 10.1111/j.1432-1033.2004.04061.x

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Cell surface adhesion of pregnancy‐associated plasma protein‐A is mediated by four clusters of basic residues located in its third and fourth CCP modulePMID 15066178Read ↗

The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity.Semantic proximity Read ↗

The Pregnancy-Associated Plasma Protein-A (PAPP-A) StorySemantic proximity Read ↗

Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.Semantic proximity Read ↗

A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module.Semantic proximity Read ↗

Biology of pregnancy‐associated plasma protein‐A in relation to prenatal diagnostics: an overviewSemantic proximity Read ↗

The role of PAPP-A in the IGF system: location, location, locationSemantic proximity Read ↗

Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease.Semantic proximity Read ↗

Pregnancy-associated plasma protein-A (PAPP-A): A local regulator of IGF bioavailability through cleavage of IGFBPsSemantic proximity Read ↗

A robust immunoassay for pregnancy-associated plasma protein-A2 based on analysis of circulating antigen: establishment of normal ranges in pregnancySemantic proximity Read ↗

Expression of recombinant murine pregnancy‐associated plasma protein‐A (PAPP‐A) and a novel variant (PAPP‐Ai) with differential proteolytic activitySemantic proximity Read ↗

Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity.Semantic proximity Read ↗

PAPP-A: a promising therapeutic target for healthy longevitySemantic proximity Read ↗

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