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Article

Mechanism of the generation of autonomous activity of Ca2+/calmodulin-dependent protein kinase IV.

The Journal of biological chemistry - 24 Sept 2004

Tokumitsu Hiroshi, Hatano Naoya, Inuzuka Hiroyuki, Yokokura Shigeyuki, Nozaki Naohito, Kobayashi Ryoji

Abstract excerpt

Ca2+/calmodulin-dependent protein kinase IV (CaM-KIV) is phosphorylated at Thr196 by Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), resulting in induction of both autonomous activity and a high level of Ca2+/CaM-dependent activity. We have shown that the kinetics of Thr196 phosphorylation of CaM-KIV by CaM-KK is well correlated with the generation of its autonomous activity, although Thr177...

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PMID: 15262966
DOI: 10.1074/jbc.M406534200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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