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Article

Phosphorylation of NF-kappa B by calmodulin-dependent kinase IV activates anti-apoptotic gene expression.

Biochemical and biophysical research communications - 13 Jun 2003

Bae Jeum Soon, Jang Moon Kyoo, Hong SunHwa, An Won Gun, Choi Yung Hyun, Kim Han Do, Cheong JaeHun

Abstract excerpt

We previously presented that calmodulin-dependent kinase IV (CaMKIV) mutually interacts with NF-kappa B and phosphorylates it directly, inducing the increased transcriptional regulation dependent on NF-kappa B target genes [J. Biol. Chem. 276 (2001) 20005]. Here, we show that Ser(535) residue is phosphorylated by CaMKIV. S535A mutant of p65 was specifically defective in transactivation of NF-kappa B target gene...

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PMID: 12767944
DOI: 10.1016/s0006-291x(03)00869-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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