Article
Beta-catenin signaling is required for neural differentiation of embryonic stem cells.
Development (Cambridge, England) - 1 Aug 2004
Otero José Javier, Fu Weimin, Kan Lixin, Cuadra Adolfo E, Kessler John A
Abstract excerpt
Culture of embryonic stem (ES) cells at high density inhibits both beta-catenin signaling and neural differentiation. ES cell density does not influence beta-catenin expression, but a greater proportion of beta-catenin is targeted for degradation in high-density cultures. Moreover, in high-density cultures, beta-catenin is preferentially localized to the membrane further reducing beta-catenin signaling....
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